Birthdating

The postnatal subplate layer in mouse contains neurons with expression of the presynaptic protein complexin 3 (Cplx3), connective tissue growth factor (CTGF), the orphan nuclear receptor Nr4a2 (Nurr1), and the G-protein-coupled lysophosphatidic acid receptor 1 (Lpar1/Edg2).

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Analyzing the variation in different subpopulations of newborn neurons is central to the study of adult hippocampal neurogenesis.We use this strategy to determine the age of cells in the cortex of the adult human brain and show that whereas nonneuronal cells are exchanged, occipital neurons are as old as the individual, supporting the view that postnatal neurogenesis does not take place in this region.Retrospective birth dating is a generally applicable strategy that can be used to measure cell turnover in man under physiological and pathological conditions.Your access to the NCBI website at gov has been temporarily blocked due to a possible misuse/abuse situation involving your site.

This is not an indication of a security issue such as a virus or attack.This information is critical, as it allows researchers to focus on aspects of the microenvironment at a specific time point that led to the production of new cells.

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